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Liver cell therapies: cellular sources and grafting strategies
《医学前沿(英文)》 2023年 第17卷 第3期 页码 432-457 doi: 10.1007/s11684-023-1002-1
关键词: liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies
Ming Zhao, Run Liu, Jian Luo, Yan Sun, Qinghong Shi
《化学科学与工程前沿(英文)》 2019年 第13卷 第1期 页码 120-132 doi: 10.1007/s11705-018-1730-y
关键词: polymer-grafted ionic exchanger grafting technique protein adsorption atom transfer radical polymerization γ-globulin
Trihydrazinotriazine-grafting Fe
Jamal Rahimi, Seyedeh Shadi Mirmohammadi, Ali Maleki
《化学科学与工程前沿(英文)》 2021年 第15卷 第4期 页码 1008-1020 doi: 10.1007/s11705-020-1996-8
关键词: trihydrazino-triazine porous magnetic nanocatalyst green chemistry tetrahydrobenzo[b]pyrans
SinoSCORE: a logistically derived additive prediction model for post-coronary artery bypass grafting
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 477-485 doi: 10.1007/s11684-013-0284-0
This study aims to construct a logistically derived additive score for predicting in-hospital mortality risk in Chinese patients undergoing coronary artery bypass surgery (CABG). Data from 9839 consecutive CABG patients in 43 Chinese centers were collected between 2007 and 2008 from the Chinese Coronary Artery Bypass Grafting Registry. This database was randomly divided into developmental and validation subsets (9:1). The data in the developmental dataset were used to develop the model using logistic regression. Calibration and discrimination characteristics were assessed using the validation dataset. Thresholds were defined for each model to distinguish different risk groups. After excluding 275 patients with incomplete information, the overall mortality rate of the remaining 9564 patients was 2.5%. The SinoSCORE model was constructed based on 11 variables: age, preoperative NYHA stage III or IV, chronic renal failure, extracardiac arteriopathy, chronic obstructive pulmonary disease, preoperative atrial fibrillation or flutter (within 2βweeks), left ventricular ejection fraction, other elective surgery, combined valve procedures, preoperative critical state, and BMI. In the developmental dataset, calibration using a Hosmer-Lemeshow (HL) test was at =β0.44 and discrimination based on the area under the receiver operating characteristic curve (ROC) was 0.80. In the validation dataset, the HL test was at =β0.34 and the area under the ROC (AUC) was 0.78. A logistically derived additive model for predicting in-hospital mortality among Chinese patients undergoing CABG was developed based on the most up-to-date multi-center data from China.
关键词: coronary artery bypass grafting risk stratification in-hospital mortality
Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu
《医学前沿(英文)》 2021年 第15卷 第1期 页码 108-115 doi: 10.1007/s11684-019-0730-8
关键词: post-transplantation cyclophosphamide allogeneic hematopoietic stem cell transplantation lymphoid malignancies
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 1-7 doi: 10.1007/s11684-010-0105-7
Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques because of donor shortage. Reduced-size liver transplantation is based on Couinaud’s anatomical classification, benefiting children and small adult recipients but failing to relieve the overall donor shortage. Split liver transplantation provides chances to two or even more recipients when only one liver graft is available. The splitting technique must follow stricter anatomical and physiological criteria either ex situ or in situto ensure long-term quality. The first and most important issue involving living donor liver transplantation is donor safety. Before surgery, a series of donor evaluations—including anatomical, liver volume, and liver function evaluations—is indispensable, followed by ethnic agreement. At different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver transplantation, which employ piggyback techniques, are good alternatives. Partial liver transplantation enriches the practice and knowledge of the transplant society.
关键词: partial liver transplantation reduced-size liver transplantation split liver transplantation living donor liver transplantation
Successful kidney transplantation in highly sensitized patients
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 80-85 doi: 10.1007/s11684-011-0115-0
Highly sensitized patients experience an increased number of rejection episodes and have poorer graft survival rates; hence, sensitization is a significant barrier to both access to and the success of organ transplantation. This study reports our experience in kidney transplantation in highly sensitized patients. Fourteen patients with sensitization or high levels of panel-reactive antibodies (PRA) were studied. All patients were desensitized with pre-transplant intravenous immunoglobulin (IVIG)/plasmapheresis (PP) with or without rituximab and thymoglobulin induction therapy, combined with a Prograf/MMF/Pred immunosuppressive regimen. Of 14 patients, 10 showed good graft functions without acute rejection (AR) episodes. Acute cellular rejection in two patients was reversed by methylprednisolone. Two patients underwent antibody-mediated rejection; one was treated with PP/IVIG successfully, whereas the other lost graft functions due to the de novoproduction of donor-specific antibodies (DSA). Graft functions were stable, and there were no AR episodes in other patients. Conclusively, desensitization using PP/IVIG with or without rituximab increases the likelihood of successful live-donor kidney transplantation in sensitized recipients.
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1470-1483 doi: 10.1007/s11705-023-2329-5
关键词: forward osmosis membrane graphene oxide quantum dots graft modification anti-fouling membrane XDLVO theory
《医学前沿(英文)》 2023年 第17卷 第1期 页码 58-67 doi: 10.1007/s11684-022-0937-y
关键词: cardiac disease mortality aged population lung transplantation
Synthesis and characterization of well-defined comb-like branched polymers
LI Aixiang, LU Zaijun, LÜ Zijian
《化学科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 407-411 doi: 10.1007/s11705-008-0064-6
关键词: grafting efficiency polyisoprene quantitative grafting effective molecular
Liver surgery and transplantation in China: Progress and Challenges
LAU W Y, LAI E C H
《医学前沿(英文)》 2007年 第1卷 第1期 页码 1-5 doi: 10.1007/s11684-007-0001-y
关键词: transplantation pyogenic cholangitis available information important hypertension
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 224-228 doi: 10.1007/s11684-017-0538-3
Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we reported six patients who underwent LTX due to BOS after HSCT (two females, four males) from January 2012 to December 2014 in our center. The median time from HSCT to diagnosis of BOS was 2.5 years (ranging from 1 to 5 years). At a median time of 4 years (ranging from 2 to 5 years) after diagnosis of BOS, four patients received bilateral sequential LTX, and two patients received single LTX. One of the recipients suffered from mild acute rejection after LTX, another suffered from primary lung graft dysfunction on post-operation day 2, and three experienced fungal infections. The median time for follow-up after LTX was 19.5 months (ranging from 12 to 39 months). At present, all patients are alive with good functional capacity and no relapse of BOS and hematologic malignancy conditions. Patients who received bilateral LTX have better pulmonary functions than patients who received single LTX.
关键词: bronchiolitis obliterans syndrome (BOS) hematopoietic stem cell transplantation (HSCT) lung transplantation (LTX)
Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 101-105 doi: 10.1007/s11684-014-0315-5
This study used different methods to establish an animal model of orthotopic transplantation for ovarian cancer to provide an accurate simulation of the mechanism by which tumor occurs and develops in the human body. We implanted 4T1 breast cancer cells stably-transfected with luciferase into BALB/c mice by using three types of orthotopic transplantation methodologies: (1) cultured cells were directly injected into the mouse ovary; (2) cell suspension was initially implanted under the skin of the mouse neck; after tumor mass formed, the tumor was removed and ground into cell suspension, which was then injected into the mouse ovary; and (3) a subcutaneous tumor mass was first generated, removed, and cut into small pieces, which were directly implanted into the mouse ovary. After these models were established, in vivo luminescence imaging was performed. Results and data were compared among groups. Orthotopic transplantation model established with subcutaneous tumor piece implantation showed a better simulation of tumor development and invasion in mice. This model also displayed negligible response to artificial factors. This study successfully established an orthotopic transplantation model of ovarian cancer with high rates of tumor formation and metastasis by using subcutaneous tumor pieces. This study also provided a methodological basis for future establishment of an animal model of ovarian cancer in humans.
Gut microbial balance and liver transplantation: alteration, management, and prediction
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 123-129 doi: 10.1007/s11684-017-0563-2
Liver transplantation is a conventional treatment for terminal stage liver diseases. However, several complications still hinder the survival rate. Intestinal barrier destruction is widely observed among patients receiving liver transplant and suffering from ischemia–reperfusion or rejection injuries because of the relationship between the intestine and the liver, both in anatomy and function. Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the process. This article reviews the research progress for gut microbial alterations and liver transplantation. Especially, this work also evaluates research on the management of gut microbial alteration and the prediction of possible injuries utilizing microbial alteration during liver transplantation. In addition, we propose possible directions for research on gut microbial alteration during liver transplantation and offer a hypothesis on the utilization of microbial alteration in liver transplantation. The aim is not only to predict perioperative injuries but also to function as a method of treatment or even inhibit the rejection of liver transplantation.
关键词: gut microbial balance liver transplantation ischemia–reperfusion acute rejection
《医学前沿(英文)》 2022年 第16卷 第5期 页码 760-765 doi: 10.1007/s11684-021-0899-5
关键词: lung transplantation donation after brain death waitlist
标题 作者 时间 类型 操作
Fabrication of high-capacity cation-exchangers for protein adsorption: Comparison of grafting-from andgrafting-to approaches
Ming Zhao, Run Liu, Jian Luo, Yan Sun, Qinghong Shi
期刊论文
SinoSCORE: a logistically derived additive prediction model for post-coronary artery bypass grafting
null
期刊论文
Fludarabine and intravenous busulfan conditioning with post-transplantation cyclophosphamide for allogeneicperipheral stem cell transplantation for adult patients with lymphoid malignancies: a prospective single-arm
Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu
期刊论文
Enhanced permeability and biofouling mitigation of forward osmosis membranes via grafting graphene quantum
期刊论文
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients
期刊论文
Synthesis and characterization of well-defined comb-like branched polymers
LI Aixiang, LU Zaijun, LÜ Zijian
期刊论文
Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation
null
期刊论文
Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
null
期刊论文